Key recent contributions to the academic literature & individual country burdens

In July 2017 the WHO published guidelines for managing advanced HIV disease and rapid initiation of anti-retroviral therapy.
WHO HIV summary      WHO HIV full guidelines

Dr Radha Rajasingham: Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis in Lancet ID May 2017

David Denning:  Roadmap for the diagnosis and management of fungal disease in Thorax 2015 

Joanne Armstead estimate the “Different manifestations of aspergillosis in cystic fibrosis adults in 30 countries”

Darius Armstrong- James et al describe “A neglected epidemic: fungal infections in HIV/AIDS” in Trends in Microbiology March 2014

Gordon Brown et al summarized the current status of fungal diseases in Science Translational Medicine in December 2012

Jeremy Day et al convincingly demonstrated that the combination of flucytosine and amphotericin B significantly reduced mortality in cryptococcal meningitis in AIDS

Angela Loyse et al found that in most subsarahan countries flucytosine is not registered and unavailable, and while amphotericin B is registered in about 50% of the countries, it is not available in most, depriving these populations of the best drugs for the very common cryptococcal meningitis.

Matthew Kneale et al published data that shows that millions of people worldwide are deprived access to antifungal medicines that are widely available elsewhere. “Global access to antifungal therapy and it’s variable cost” was published in August 2016.

David Denning constructed scenarios to estimate avoidable deaths from 2016 to 2020 and showed that 550 AIDS patients can be saved every day by detecting and treating fungal infections.

David Denning has recently published an Editorial calling upon all public health mycologists



O’Neill report: Antimicrobials in Agriculture & the Environment

O’Neill report: Rapid Diagnostics & Stopping Unecessary Use of Antibiotics 

WHO report: Universal Eye Health – A global action plan 2014-2019

ECDC report: Risk assessment on the impact of environmental usage of triazoles on the development and spread of resistance to medical triazoles in Aspergillus species

WHO report: Mycetoma a neglected tropical disease.


Individual country burden estimates:


Algeria, Chekiri-Talbi, Eur J Clin Microbiol Infect Dis, 2017;

Argentina, Riera, J. Fungi, 2018

Austria Mycoses 2015;

Bangladesh, Gugnani, Eur J Clin Microbiol Infect Dis, 2017;

Belgium, Lagrou Mycoses 2015;

Brazil, Giacomazzi, 2016;

Burkino Faso, Bamba, 2018

Cameroon, Mandengue, J. Fungi, 2018

Canada, Dufresne, Eur J Clin Microbiol Infect Dis, 2017;

Chile, Duarte, Eur J Clin Microbiol Infect Dis, 2017;

Colombia, Alvarez-Moreno, J. Fungi, 2018

Czech Republic, Chrdle Mycoses 2015;

Denmark, Mortensen Mycoses2015;

Dominican Republic, Gugnani Mycoses 2015;

Ecuador, Zurita, Eur J Clin Microbiol Infect Dis, 2017;

Egypt, Zaki, Eur J Clin Microbiol Infect Dis, 2017;

France, Gangneux, J. Mycol Med. 2016;

Germany, Ruhnke Mycoses 2015;

Greece, Gamaletsou . Eur J Clin Microbiol. Inf dis 2016;

Guatemala, Medina, Eur J Clin Microbiol Inf Dis 2017

Hungary, Sinko Mycoses 2015;

India, Agarwal Mycoses 2015;

Ireland, Dorgan Mycoses 2015;

Israel, Ben-Ami Mycoses 2015;

Jamaica, Gugnani Mycoses 2015;

Jordan, Wadi, 2018

Kazakhstan, Kemaikin, V. M. Problems of Medical Mycology, 2016;   & Kemaikin 2018

Kenya, Guto JIDC, 2016;

Korea, Huh, Eur J Clin Microbiol Inf Dis, 2017;

Malawi, Kalua, J. Fungi, 2018

Malaysia, Devi Velayuthan, J. Fungi, 2018

Mexico, Corzo-Leon Mycoses 2015;

Nepal, Shrestha Mycoses 2015;

Nigeria, Oladele Mycoses 2015;

Norway, Nordoy 2018

Pakistan, Jabeen, Eur J Clin Microbiol Infect Dis, 2017;

Peru, Bustamante, Eur J Clin Microbiol Infect Dis, 2017;

Phillipines, Batac, Eur J Clin Microbiol Infect Dis, 2017;

Portugal, Sabino, Eur J Clin Microbiol Infect Dis, 2017;

Qatar, Taj-Aldeen Mycoses 2015;

Romania, Mares, 2018

Russia, Klimko Mycoses 2015;

Senegal, Badiane Mycoses 2015;

Spain, Rodriguez Mycoses 2015;

Sri Lanka, Jaysakera Mycoses 2015;

Tanzania, Faini Mycoses 2015;

Thailand, Chayakulkeeree, Eur J Clin Microbiol Infect Dis, 2017;

Trinidad and Tobago, Denning Mycoses 2015;

Uganda, Parkes-Ratanshi Mycoses 2015;

Ukraine, Osmanov Mycoses 2015;

United Kingdom J.Infection 2016;

Uruguay, Macedo-Vinas, J. Fungi, 2018

Uzbekistan, Tilavberdiev, Republic of, Eur J Clin Microbiol Infect Dis, 2017;

Vietnam, Beardsley Mycoses 2015;