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News

Keep up to date with the latest news items from GAFFI.

GAFFI calls together experts in Lima to formulate new thinking on fungal disease management in Latin America

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July 1st 2020 15:00 BST (GMT+1) For Spanish version click here Briefing webinar: https://us02web.zoom.us/j/82914301088 For further details of the briefing visit ECMM website September 3-5th over 60 fungal disease experts from Argentina, Brazil, Chile, Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Uruguay and Venezuela convened in… Read more »

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PAHO issues guidelines on disseminated histoplasmosis in HIV/AIDS

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Disseminated histoplasmosis is under-diagnosed and as a result, is the cause of death in up to 20% of people dying of AIDS. Antigen detection in serum or urine is more sensitive and faster than conventional diagnosis, usually based on culture, or histopathology of skin lesions or bone marrow.  Today the Pan American Health Organization has… Read more »

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GAFFI Ambassadors shine light on decades of mycetoma in Senegal and Uganda

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Mycetoma is a chronic granulomatous deep mycosis that causes debilitating lesions, caused by fungal or bacterial implantation through the skin. In Uganda, Richard Kwizera, Dr Felix Bongomin and colleagues in Kampala published a 69 year retrospective study of all biopsy reports produced by the Pathology Reference Laboratory at Makerere University from 1950 to 2019 (249… Read more »

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How common is chronic pulmonary histoplasmosis? No one knows, but it is likely global and grossly under-diagnosed

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First described in in 1948 and acknowledged as a separate clinical entity in 1953, many patients with chronic pulmonary histoplasmosis (CPH) languished in US tuberculosis sanatoriums, until picked out in the 1950’s. In one sanatorium in Missouri, 7.2% of ‘TB patients’ actually had CPH. In a review just published in Open Forum Infectious Diseases, Jacob… Read more »

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On World Tuberculosis Day, remember TB-like fungal infections and co-infection of TB and Aspergillus

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  Several lung fungal infections can be mistaken for TB – histoplasmosis, aspergillosis, coccidioidomycosis and paracoccidioidomycosis.  Antibody testing and fungal culture of sputum are the means of establishing the diagnosis. The number of incident cases of these fungal infections varies substantially by region and country and the rate of misdiagnosis of TB-like fungal infections is not… Read more »

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Neglected, market failures, public health failures

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  Writing in PLoS Neglected Tropical Diseases, Marcio Rodrigues and Joshua Nosanchuk highlight the numerous reasons why fungal diseases are so neglected. They point to a science failure – including inadequate funding. They detail research funding for different diseases by numbers of deaths: malaria $1,315 , tuberculosis $334, diarrhoeal diseases $276, compared with $31 for… Read more »

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World’s first lateral flow assay for Histoplasma antigen launched

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In a ground-breaking development for patients with AIDS, the world’s first lateral flow assay able to detect Histoplasma antigen has been launched by MiraVista Diagnostics, based in Indianapolis, USA. Diego Cáceres and colleagues at the Centers for Disease Control and Prevention (CDC) independently evaluated the new LFA in serum samples from patients and controls in… Read more »

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Candida bloodstream infection in the USA

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A recent CDC Morbidity & Mortality Weekly Report estimated the incidence of candidaemia in the US at around 9/100,000 which equates to >28,000 cases annually, with an overall mortality of 25%. 10% of cases are in IV drug abusers, 33% in diabetics and 17% in cancer patients.

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The Diagnostic Laboratory Hub – a new Healthcare System to reduce fungal disease mortality in Guatemala

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A team from Guatemala has published a new approach to diagnosing AIDS-related lethal fungal infections and tuberculosis (TB) in the prestigious journal Open Forum Infectious Diseases. Supported by the Global Action Fund for Fungal Infections (GAFFI) the Asociación de Salud Integral shows how by providing access to rapid diagnostics and focussed training, LMICs can deliver… Read more »

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