Our Successes

  1. GAFFI and its partners have estimated the global burden of serious fungal infections for >6 billion people (over 80% of the world’s population) including Algeria, Argentina, Australia, Austria, Azerbaijan, Bangladesh, Belgium, Belarus, Benin, Bolivia, Brazil, Burkina Faso, Cameroon, Canada, Chile, China, Congo, Congo (Republic of), Costa Rica, Cote d’Ivoire, Cuba, Czech Republic, Denmark, Dominican Republic, Ecuador, Egypt, Ethiopia, France, Germany,  Ghana, Greece, Guatemala, Honduras, Hungary, India (3 topics), Indonesia, Iran, Iraq, Ireland, Israel, Italy, Jamaica, Japan, Jordan, Kazakhstan, Kenya, Kyrgyzstan, Madagascar, Malawi, Malaysia, Mexico, Mongolia, Mozambique, Namibia, Nepal, Netherlands, New Zealand, Nicaragua, Nigeria, Norway, Qatar, Pakistan, Panama, Paraguay, Peru, Philippines, Portugal, Romania, Russia, Saudi Arabia, Senegal, Serbia, Singapore, South Africa, South Korea, Spain, Sri Lanka, Sudan, Sweden, Taiwan, Tanzania, Thailand, Tijakistan, Trinidad and Tobago, Togo, Turkey, Uganda, UK, Ukraine, Uruguay, Uzbekistan, Venezuela, Vietnam and Zambia: https://www.gaffi.org/media/academic-papers/
  2. Successfully lobbied the WHO to place itraconazole, voriconazole and natamycin 5% ophthalmic solution onto the Essential Medicines List (EML) to treat aspergillosis, histoplasmosis, sporotrichosis, chromoblastomycosis T. marneffei infection and other skin infection, as well as fungal keratitis, in a coalition with the Instituto de Salud Carlos III, International Foundation for Dermatology, London School of Hygiene of Tropical Medicine and The University of Manchester. https://www.gaffi.org/ruling-by-world-health-organisation-delights-doctors/
  3. Successfully lobbied the WHO to place amphotericin B and flucytosine on the Essential Medicines List to treat cryptococcal meningitis and other life-threatening fungal infections, in a coalition with other agencies including US Centres for Disease Control, attendees from LIFE, WHO, Medicines Sans Frontieres (MSF), Clinton Health Access and numerous universities and public health institutions.”  View selection and use of Essential Medicines.
  4. Launched the 10 year Roadmap ‘95-95 by 2025’ at ISHAM conference in Melbourne, calling on all national governments and public health agencies to reduce the toll of death and blindness from fungal diseases. 95-95 means 95% of patients with life or sight-threatening fungal disease will be  diagnosed and 95% treated by 2025. GAFFI proposed a target of reducing AIDS deaths to under 500,000 by 2020, which has been adopted by UNAIDS as a key target.  10 year ’95-95 by 2025′ GAFFI Roadmap.
  5. Documented the availability and cost of generic antifungal (amphotericin B, fluconazole, itraconazole and flucytosine) in almost all countries (see the maps here) and published: https://www.gaffi.org/limited-availability-of-generic-antifungals-across-the-world/
  6. Influenced the WHO to include several key diagnostic tests for fungi on the first Model List of in vitro Diagnostic Tests including microscopy, fungal culture, blood culture and cryptococcal antigen testing. View Global Fungal Infection Forum 3 Report. View press release on WHO Essential Diagnostics List.
  7. Successfully applied for the WHO to recommend to the World Health Assembly for the disfiguring skin disease chromoblastomycosis to be included as a Neglected Tropical Disease (NTD), with support form the governments of Brazil and Madagascar. View press release.
  8. GAFFI’s Chief Executive has contributed the world’s first clinical guidelines for chronic pulmonary aspergillosis and contributed to the Infectious Diseases Society of America updated guidelines for aspergillosis.
  9. GAFFI has pointed out in a perspective published in the CDC journal Emerging Infectious Diseases that availability of rapid, non-culture based diagnostics for fungal diseases are essential in the fight against Antimicrobial Resistance (AMR) by limiting unnecessary anti-bacterial therapy. View press release.
  10. GAFFI has modelled how many lives could be saved from AIDS over 5 years with 60% implementation of fungal diagnostics and antifungal drug availability for cryptococcal meningitis, disseminated histoplasmosis, Pneumocystis pneumonia (PCP) and chronic pulmonary aspergillosis – over 1 million. View press release.
  11. GAFFI has drafted the revisions to the International Classification of Diseases (currently ICD10) to be incorporated into ICD11, in collaboration with the WHO. This is crucial to collection of data internationally, as data is coded using ICD codes all over the world.
  12. Developed consensus recommendations on the diagnosis of chronic pulmonary aspergillosis after TB, so often mis-diagnosed as ‘smear negative TB. View Global Fungal Infection Forum 2 Report. View press release.
  13. GAFFI is implementing a national program of fungal disease diagnosis and management in AIDS in Guatemala and has initiated one in Kenya.
  14. Supported the cryptococcal disease access programme (CryptoMAG), a collaboration between the WHO (HIV Treatment and Care), CDC (Mycotic Diseases Branch), MSF (Access Campaign), Clinton Health Access Initiative and Management Sciences for Health (Technical Strategy and Quality Center for Pharmaceutical Management).
  15. Supports the Histoplasmosis Action Group (HistoAG) a collaboration between numerous clinicians and researchers, the US Centers for Disease Control, Caribbean Public Health Agency and Prevention and the Pan-American Health Organisation which issued the Manaus Declaration in March 2019 calling for “ Every American country to have  access to rapid testing for histoplasmosis (antigen or PCR/molecular) and availability of itraconazole and both standard and lipid formulations of amphotericin B.” View